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Article

The role of DNA mismatch repair in generating genetic diversity and drug resistance in malaria parasites.

Molecular and biochemical parasitology - 1 Sept 2007

Bethke Lara, Thomas Susan, Walker Kerone, Lakhia Ronak, Rangarajan Radha, Wirth Dyann

Abstract excerpt

Although the mechanisms by which malaria parasites develop resistance to drugs are unclear, current knowledge suggests a main mechanism of resistance is the alteration of target enzymes by point mutation. In other organisms, defects in DNA mismatch repair have been linked to increased mutation rates and drug resistance. We have identified an unusual complement of mismatch repair genes in the Plasmodium genome. An...

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Identifiers

PMID: 17583362
DOI: 10.1016/j.molbiopara.2007.05.003
PMCID: PMC3683857

Genes

MSH2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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