Article
ISHAPE: new rapid and accurate software for haplotyping.
BMC bioinformatics - 15 Jun 2007
Delaneau Olivier, Coulonges Cédric, Boelle Pierre-Yves, Nelson George, Spadoni Jean-Louis, Zagury Jean-François
Abstract excerpt
BACKGROUND: We have developed a new haplotyping program based on the combination of an iterative multiallelic EM algorithm (IEM), bootstrap resampling and a pseudo Gibbs sampler. The use of the IEM-bootstrap procedure considerably reduces the space of possible haplotype configurations to be explored, greatly reducing computation time, while the adaptation of the Gibbs sampler with a recombination model on this...
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