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Article

Selection of cervical keratinocytes containing integrated HPV16 associates with episome loss and an endogenous antiviral response

27 Feb 2006

Abstract excerpt

Integration of high-risk human papillomavirus (HRHPV) into the host genome is a key event in cervical neoplastic progression. Integration is associated with deregulated expression of the viral oncogenes E6 and E7 and acquisition of a selective growth advantage for cells containing integrants. Overexpression of the viral transcriptional regulator E2 from heterologous promoters has an inhibitory effect on...

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PMID: 16505361
DOI: 10.1073/pnas.0600078103

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