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Article

Analysis of polymorphisms of tumor necrosis factor-alpha and polymorphic xenobiotic metabolizing enzymes in inflammatory bowel disease: study from northern India.

Journal of gastroenterology and hepatology - 1 Jun 2007

Mittal Rama D, Manchanda Parmeet K, Bid Hemant K, Ghoshal Uday C

Abstract excerpt

BACKGROUND: Tumor necrosis factor (TNF)-alpha is a proinflammatory cytokine associated with inflammatory diseases, while GSTM1 and T1 enzymes catalyze detoxification of products of oxidative stress and hence reduce inflammation. Thus, both may play important roles in the pathogenesis of inflammatory bowel disease (IBD). The present study aimed to evaluate the effect of polymorphism of the TNF-alpha promoter at...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17565649
DOI: 10.1111/j.1440-1746.2006.04538.x

Genes

GSTM1
TNF
GSTT1

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