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Article

Large-scale identification of human genes implicated in epidermal barrier function

11 Jun 2007

Abstract excerpt

BACKGROUND: During epidermal differentiation, keratinocytes progressing through the suprabasal layers undergo complex and tightly regulated biochemical modifications leading to cornification and desquamation. The last living cells, the granular keratinocytes (GKs), produce almost all of the proteins and lipids required for the protective barrier function before their programmed cell death gives rise to...

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PMID: 17562024
DOI: 10.1186/gb-2007-8-6-r107

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