Article
The role of nitric oxide in muscle fibers with oxidative phosphorylation defects.
Biochemical and biophysical research communications - 3 Aug 2007
Tengan Célia H, Kiyomoto Beatriz H, Godinho Rosely O, Gamba Juliana, Neves Afonso C, Schmidt Beny, Oliveira Acary S B, Gabbai Alberto A
Abstract excerpt
NO has been pointed as an important player in the control of mitochondrial respiration, especially because of its inhibitory effect on cytochrome c oxidase (COX). However, all the events involved in this control are still not completely elucidated. We demonstrate compartmentalized abnormalities on nitric oxide synthase (NOS) activity on muscle biopsies of patients with mitochondrial diseases. NOS activity was...
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