Article

Peroxiredoxin 2 mediates redox-stimulated adaptations to oxidative phosphorylation induced by contractile activity in human skeletal muscle myotubes

2024-09-24

Abstract excerpt

Skeletal muscle generates superoxide during contractions, which is converted to hydrogen peroxide (H 2 O 2 ). H 2 O 2 has been proposed to activate signalling pathways and transcription factors that regulate adaptive responses to exercise, but the concentration required to oxidize and activate key redox-sensitive signalling proteins in vitro is much higher than the typical intracellular levels seen in muscle...

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Literature Corpus work: 1f7249fc-d2ae-5a43-855b-2f788f8be2d5
DOI: 10.1101/2024.09.23.611634

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