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Article

Nitric oxide synthesis is increased in cybrid cells with m.3243A>G mutation.

International journal of molecular sciences - 24 Dec 2012

Gamba Juliana, Gamba Luana T, Rodrigues Gabriela S, Kiyomoto Beatriz H, Moraes Carlos T, Tengan Celia H

Abstract excerpt

Nitric oxide (NO) is a free radical and a signaling molecule in several pathways, produced by nitric oxide synthase (NOS) from the conversion of L-arginine to citrulline. Supplementation of L-arginine has been used to treat MELAS (mitochondrial encephalopathy with lactic acidosis and stroke like syndrome), a mitochondrial disease caused by the m.3243A>G mutation. Low levels of serum arginine and endothelium...

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PMID: 23263669
DOI: 10.3390/ijms14010394
PMCID: PMC3565270

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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