Article
Reemergence of chloroquine-sensitive Plasmodium falciparum malaria after cessation of chloroquine use in Malawi.
The Journal of infectious diseases - 15 Jun 2003
Kublin James G, Cortese Joseph F, Njunju Eric Mbindo, Mukadam Rabia A G, Wirima Jack J, Kazembe Peter N, Djimdé Abdoulaye A, Kouriba Bourema, Taylor Terrie E, Plowe Christopher V
Abstract excerpt
In 1993, Malawi became the first African country to replace chloroquine with sulfadoxine-pyrimethamine nationwide in response to high rates of chloroquine-resistant falciparum malaria. To determine whether withdrawal of chloroquine can lead to the reemergence of chloroquine sensitivity, the prevalence of the pfcrt 76T molecular marker for chloroquine-resistant Plasmodium falciparum malaria was retrospectively...
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