Article
Environment determines fidelity for an RNA virus replicase.
Journal of virology - 1 Sept 2007
Pita Justin S, de Miranda Joachim R, Schneider William L, Roossinck Marilyn J
Abstract excerpt
The rate of insertion and deletion mutations of the replicase of Cucumber mosaic virus (CMV) was determined in planta by using a parasitic satellite RNA (satRNA) as a reporter. We found that the CMV replicase had different fidelity in different environments, with important implications in viral disease evolution. Insertions were very rare events, irrespective of the region of the satRNA genome assayed and...
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