Article
Tissue-Specific and Inducer-Specific Differential Induction of ISG56 and ISG54 in Mice
7 Jun 2007
Abstract excerpt
The interferon-stimulated genes (ISGs) ISG56 and ISG54 are strongly induced in cultured cells by type I interferons (IFNs), viruses, and double-stranded RNA (dsRNA), which activate their transcription by various signaling pathways. Here we studied the stimulus-dependent induction of both genes in vivo. dsRNA, which is generated during virus infection, induced the expression of both genes in all organs examined....
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