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Article

Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis.

Zoological science - 1 Mar 2007

Hirobe Tomohisa, Wakamatsu Kazumasa, Ito Shosuke

Abstract excerpt

The mouse slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase (DCT). The reduced DCT activity inhibits melanosome maturation and reduces the melanin content in the skin, hair and eyes. It is not known whether eumelanin and pheomelanin synthesis in slaty melanocytes is modulated by melanogenic factors. In this study, to address this point, epidermal melanocytes derived from 0.5-,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17551240
DOI: 10.2108/zsj.24.209

Genes

DCT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis.PMID 17551240Read ↗

The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes.Semantic proximity Read ↗

Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutation.Semantic proximity Read ↗

The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes.Semantic proximity Read ↗

Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine.Semantic proximity Read ↗

Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice.Semantic proximity Read ↗

[Effects of mutation in dopachrome tautomerase on melanosome maturation and anti-oxidative potential in cultured melanocytes].Semantic proximity Read ↗

Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty alleles.Semantic proximity Read ↗

Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice.Semantic proximity Read ↗

A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.Semantic proximity Read ↗

Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes.Semantic proximity Read ↗

The mouse brown (b/Tyrp1(b) ) allele does not affect pheomelanin synthesis in mice.Semantic proximity Read ↗

Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture.Semantic proximity Read ↗

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