Article
Role of tyrosinase as the determinant of pigmentation in cultured human melanocytes.
The Journal of investigative dermatology - 1 Jun 1993
Iozumi K, Hoganson G E, Pennella R, Everett M A, Fuller B B
Abstract excerpt
Variations in human pigmentation among different racial groups are due to differences in the production and deposition of melanin in the skin. Although melanin synthesis is known to be controlled by the rate-limiting enzyme tyrosinase, the role of this enzyme as the principal determinant of skin pigmentation is unclear. Results from studies with human melanocyte cultures derived from different racial skin types...
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