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Article

The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes.

European journal of cell biology - 1 Jun 2006

Hirobe Tomohisa, Wakamatsu Kazumasa, Ito Shosuke, Kawa Yoko, Soma Yoshinao, Mizoguchi Masako

Abstract excerpt

The slaty (Dct(slt)) mutation is known to reduce the activity of dopachrome tautomerase (DCT) in melanocytes. However, it is unknown whether the reduced DCT activity leads to a defect in the proliferation and differentiation of mouse melanocytes. To address this point, the proliferation and differentiation of neonatal melanocytes from Dct(slt)/Dct(slt) congenic mice in serum-free primary culture were investigated...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16584806
DOI: 10.1016/j.ejcb.2006.01.013

Genes

DCT
TYR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The slaty mutation affects eumelanin and pheomelanin synthesis in mouse melanocytes.PMID 16584806Read ↗

Excess tyrosine stimulates eumelanin and pheomelanin synthesis in cultured slaty melanocytes from neonatal mouse epidermis.Semantic proximity Read ↗

The slaty mutation affects the morphology and maturation of melanosomes in the mouse melanocytes.Semantic proximity Read ↗

Excess tyrosine restores the morphology and maturation of melanosomes affected by the murine slaty mutation.Semantic proximity Read ↗

Changes of melanosome morphology associated with the differentiation of epidermal melanocytes in slaty mice.Semantic proximity Read ↗

Structure of the mouse tyrosinase-related protein-2/dopachrome tautomerase (Tyrp2/Dct) gene and sequence of two novel slaty alleles.Semantic proximity Read ↗

Melanocytes and pigmentation are affected in dopachrome tautomerase knockout mice.Semantic proximity Read ↗

[Effects of mutation in dopachrome tautomerase on melanosome maturation and anti-oxidative potential in cultured melanocytes].Semantic proximity Read ↗

A second tyrosinase-related protein, TRP-2, maps to and is mutated at the mouse slaty locus.Semantic proximity Read ↗

Changes in the proliferation and differentiation of neonatal mouse pink-eyed dilution melanocytes in the presence of excess tyrosine.Semantic proximity Read ↗

Mutant alleles at the brown locus encoding tyrosinase-related protein-1 (TRP-1) affect proliferation of mouse melanocytes in culture.Semantic proximity Read ↗

The mouse brown (b/Tyrp1(b) ) allele does not affect pheomelanin synthesis in mice.Semantic proximity Read ↗

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