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Article

Halide binding by the D212N mutant of Bacteriorhodopsin affects hydrogen bonding of water in the active site.

Biochemistry - 26 Jun 2007

Shibata Mikihiro, Yoshitsugu Maiko, Mizuide Noriko, Ihara Kunio, Kandori Hideki

Abstract excerpt

Bacteriorhodopsin (BR), a membrane protein found in Halobacterium salinarum, functions as a light-driven proton pump. The Schiff base region has a quadrupolar structure with positive charges located at the protonated Schiff base and Arg82, and the counterbalancing negative charges located at Asp85 and Asp212. The quadropole inside the protein is stabilized by three water molecules, forming a roughly planar...

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Identifiers

PMID: 17547422
DOI: 10.1021/bi7004224

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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