Article
The crystal structures of a chloride-pumping microbial rhodopsin and its proton-pumping mutant illuminate proton transfer determinants.
The Journal of biological chemistry - 30 Oct 2020
Besaw Jessica E, Ou Wei-Lin, Morizumi Takefumi, Eger Bryan T, Sanchez Vasquez Juan D, Chu Jessica H Y, Harris Andrew, Brown Leonid S, Miller R J Dwayne, Ernst Oliver P
Abstract excerpt
Microbial rhodopsins are versatile and ubiquitous retinal-binding proteins that function as light-driven ion pumps, light-gated ion channels, and photosensors, with potential utility as optogenetic tools for altering membrane potential in target cells. Insights from crystal structures have been central for understanding proton, sodium, and chloride transport mechanisms of microbial rhodopsins. Two of three known...
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