Article
Mutations of the PIK3CA gene in hereditary colorectal cancers.
International journal of cancer - 1 Oct 2007
Miyaki Michiko, Iijima Takeru, Yamaguchi Tatsuro, Takahashi Keiichi, Matsumoto Hiroshi, Yasutome Michiya, Funata Nobuaki, Mori Takeo
Abstract excerpt
Somatic mutations of the PIK3CA gene have recently been detected in various human cancers, including sporadic colorectal cancer. However, mutations of the PIK3CA gene in hereditary colorectal cancers have not been clarified. To elucidate the mutation status in familial adenomatous polyposis (FAP) and hereditary nonpolyposis colorectal cancer (HNPCC), which are the most common hereditary colorectal cancers, we...
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