Article
Analysis of synapsin III-196 promoter mutation in schizophrenia and bipolar disorder.
Neuropsychobiology - 1 Jan 2006
Lachman Herbert M, Stopkova Pavla, Papolos Demitri F, Pedrosa Erika, Margolis Benjamin, Aghalar Maryam Rafael, Saito Takuya
Abstract excerpt
BACKGROUND: The 22q13-linked gene synapsin III is a positional candidate gene for schizophrenia (SZ). One interesting synapsin III single nucleotide polymorphism (SNP), -196G/A, has been identified in the promoter region. The -196A allele results in a 6/8 base match to the core recognition octamer sequence for Oct-1, a member of the POU family of transcription factors. OBJECTIVE: To determine whether or not the...
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