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Article

PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.

Developmental biology - 15 Jul 2007

Kim Doyeob, Dressler Gregory R

Abstract excerpt

The RET receptor tyrosine kinase is activated by GDNF and controls outgrowth and invasion of the ureteric bud epithelia in the developing kidney. In renal epithelial cells and in enteric neuronal precursor cells, activation of RET results in chemotaxis as Ret expressing cells invade the surroundi...

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Share to Glial Cell Line-Derived Neurotrophic Factor
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Phosphatidylinositol 3-Kinases

Share to Phosphatidylinositol Phosphates

Share to Proto-Oncogene Proteins c-ret

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Source

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Identifiers

PMID: 17540362
DOI: 10.1016/j.ydbio.2007.04.051
PMCID: PMC2129124

Genes

RET
PTEN
GDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17540362-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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PTEN modulates GDNF/RET mediated chemotaxis and branching morphogenesis in the developing kidney.PMID 17540362Read ↗

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PTEN downregulates p75NTR expression by decreasing DNA-binding activity of Sp1.Semantic proximity Read ↗

GDNF/Ret signaling and the development of the kidneySemantic proximity Read ↗

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Ret signaling in ureteric bud epithelial cells controls cell movements, cell clustering and bud formationSemantic proximity Read ↗

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