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Article

FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.

Nature genetics - 1 Jun 2007

Fanciulli Manuela, Norsworthy Penny J, Petretto Enrico, Dong Rong, Harper Lorraine, Kamesh Lavanya, Heward Joanne M, Gough Stephen C L, de Smith Adam, Blakemore Alexandra I F, Froguel Philippe, Owen Catherine J, Pearce Simon H S, Teixeira Luis, Guillevin Loic, Graham Deborah S Cunninghame, Pusey Charles D, Cook H Terence, Vyse Timothy J, Aitman Timothy J

Abstract excerpt

Naturally occurring variation in gene copy number is increasingly recognized as a heritable source of susceptibility to genetically complex diseases. Here we report strong association between FCGR3B copy number and risk of systemic lupus erythematosus (P = 2.7 x 10(-8)), microscopic polyangiitis...

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Identifiers

PMID: 17529978
DOI: 10.1038/ng2046
PMCID: PMC2742197

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17529978-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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FCGR3B copy number variation is associated with susceptibility to systemic, but not organ-specific, autoimmunity.PMID 17529978Read ↗

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