Impaired retinal differentiation and maintenance in zebrafish laminin mutants.

doi:10.1167/iovs.06-1212

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Article

Impaired retinal differentiation and maintenance in zebrafish laminin mutants.

Investigative ophthalmology & visual science - 1 Jun 2007

Biehlmaier Oliver, Makhankov Yuri, Neuhauss Stephan C F

Abstract excerpt

PURPOSE: To characterize morphologic and physiological alterations in the retina of three laminin mutant zebrafish, bashful (bal, lama1), grumpy (gup, lamb1), and sleepy (sly, lamc1), which were identified in forward genetic screens and were found to be impaired in visual functions. METHODS: Mutant larvae were observed for defects in visual behavior by testing their optokinetic response (OKR). In addition,...

Topics

Animals
Cell Differentiation
Electroretinography
Embryo, Nonmammalian
Fluorescent Antibody Technique, Indirect
In Situ Nick-End Labeling
Laminin
Lens, Crystalline
Microscopy, Fluorescence
Morphogenesis
Mutation
Nystagmus, Optokinetic
Optic Nerve
Retina
Retinal Ganglion Cells
Zebrafish
Zebrafish Proteins

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Open in PubMed

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PMID: 17525225
DOI: 10.1167/iovs.06-1212

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