Article
Blind But Alive - Congenital Loss of atoh7 Disrupts the Visual System of Adult Zebrafish.
Investigative ophthalmology & visual science - 4 Nov 2024
Hammer Juliane, Röppenack Paul, Yousuf Sarah, Machate Anja, Fischer Marika, Hans Stefan, Brand Michael
Abstract excerpt
Purpose: Vision is the predominant sense in most animal species. Loss of vision can be caused by a multitude of factors resulting in anatomic as well as behavioral changes. In mice and zebrafish, atoh7 mutants are completely blind as they fail to generate retinal ganglion cells (RGCs) during development. In contrast to mice, raising blind zebrafish to adulthood is challenging and this important model is currently...
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