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Article

Age-related cataracts in alpha3Cx46-knockout mice are dependent on a calpain 3 isoform.

Investigative ophthalmology & visual science - 1 Jun 2007

Tang Yajun, Liu Xiangyang, Zoltoski Rebecca K, Novak Layne A, Herrera R Antonio, Richard Isabelle, Kuszak Jer R, Kumar Nalin M

Abstract excerpt

PURPOSE: Previous studies have demonstrated that in 129alpha3Cx46-/- mice, age-related nuclear cataract is formed. In the present study, a more in vivo-relevant model was generated to test the hypothesis that the calpain 3 gene is involved in age-related nuclear cataractogenesis in alpha3Cx46 kno...

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Source

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Identifiers

PMID: 17525200
DOI: 10.1167/iovs.06-0926
PMCID: PMC1959511

Genes

CAPN3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17525200-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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