Article
Genetic factors influence cataract formation in alpha 3 connexin knockout mice.
Developmental genetics - 1 Jan 1999
Gong X, Agopian K, Kumar N M, Gilula N B
Abstract excerpt
Connexin alpha 3 (Cx46 or Gja3) gene targeted null mice developed lens nuclear cataracts shortly after birth. A large variance in the cataracts was observed in alpha 3 null sibs on a mixed 129SvJae X C57BL/6J F3 background. This suggested that the genetic background might influence the cataract phenotype. Therefore, we placed the alpha 3 null mutation into a 129SvJae background, and also backcrossed the mutation...
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