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Article

Developmental truncations of connexin 50 by caspases adaptively regulate gap junctions/hemichannels and protect lens cells against ultraviolet radiation.

The Journal of biological chemistry - 4 May 2012

Wang Ke, Gu Sumin, Yin Xinye, Weintraub Susan T, Hua Zichun, Jiang Jean X

Abstract excerpt

The gap junction-forming connexin (Cx) 50 is truncated gradually during lens development. Premature cleavage of lens connexins is thought to be associated with cataract formation. We have shown previously that Cx50 is likely to be cleaved by caspase-3 like protease during chick lens development. Here, using HPLC-electrospray tandem mass spectrometry, we mapped two cleavage sites at the C terminus of Cx50 after...

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Identifiers

PMID: 22418432
DOI: 10.1074/jbc.M111.313171
PMCID: PMC3346145

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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