Article
Use of peripheral blood DNA for genotype antiretroviral resistance testing in drug-naive HIV-infected subjects.
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America - 15 Jun 2007
Vicenti Ilaria, Razzolini Francesca, Saladini Francesco, Romano Laura, Zazzi Maurizio
Abstract excerpt
Parallel analysis of peripheral blood mononuclear cell DNA and plasma RNA from 169 drug-naive human immunodeficiency virus-infected subjects revealed that evaluation of both compartments increases the sensitivity of detection of drug resistance-related mutations, compared with examination of either source alone. Peripheral blood mononuclear cell DNA may play a role in the surveillance of transmitted...
Topics
- Anti-Retroviral Agents
- DNA, Viral
- Drug Resistance, Viral
- HIV
- HIV Infections
- Humans
- Leukocytes, Mononuclear
- Molecular Sequence Data
- Mutation
- Sensitivity and Specificity