Article
Elevated circulating level of osteopontin is associated with advanced disease state of non-small cell lung cancer.
Lung cancer (Amsterdam, Netherlands) - 1 Sept 2007
Chang Yoon Soo, Kim Hyung Jung, Chang Joon, Ahn Chul Min, Kim Sung Kyu, Kim Se Kyu
Abstract excerpt
Osteopontin (OPN) plays important roles in tumor progression and metastasis through binding to OPN receptors such as alpha(v)beta(beta) integrin and CD44, and its overexpression in tumor is associated poor clinical outcome of NSCLC patients. Circulating OPN levels, measured by ELISA in 130 NSCLC...
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