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Article

Inherited susceptibility to lung cancer may be associated with the T790M drug resistance mutation in EGFR.

Nature genetics - 1 Dec 2005

Bell Daphne W, Gore Ira, Okimoto Ross A, Godin-Heymann Nadia, Sordella Raffaella, Mulloy Roseann, Sharma Sreenath V, Brannigan Brian W, Mohapatra Gayatry, Settleman Jeff, Haber Daniel A

Abstract excerpt

Somatic activating mutations in EGFR identify a subset of non-small cell lung cancer that respond to tyrosine kinase inhibitors. Acquisition of drug resistance is linked to a specific secondary somatic mutation, EGFR T790M. Here we describe a family with multiple cases of non-small cell lung cancer associated with germline transmission of this mutation. Four of six tumors analyzed showed a secondary somatic...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 16258541
DOI: 10.1038/ng1671

Genes

EGFR

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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