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Article

Germline EGFR T790M mutation found in multiple members of a familial cohort.

Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer - 1 Apr 2014

Yu Helena A, Arcila Maria E, Harlan Fleischut Megan, Stadler Zsofia, Ladanyi Marc, Berger Michael F, Robson Mark, Riely Gregory J

Abstract excerpt

Activating mutations in epidermal growth factor receptor (EGFR) are present in a subset of lung cancers, and predict sensitivity to EGFR tyrosine kinase inhibitors. Acquisition of EGFR T790M is the most common mechanism of resistance to EGFR tyrosine kinase inhibitors and rarely is seen before treatment. Germline EGFR T790M mutations have been reported, although the penetrance and clinical significance of this...

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Source

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Identifiers

PMID: 24736080
DOI: 10.1097/JTO.0000000000000052
PMCID: PMC4412273

Genes

EGFR

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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