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Article

Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypes.

Clinical chemistry - 1 Jul 2007

Zhu Yusheng, Shennan Michael, Reynolds Kristen K, Johnson Nancy A, Herrnberger Matthew R, Valdes Roland, Linder Mark W

Abstract excerpt

BACKGROUND: CYP2C9 polymorphisms are associated with decreased S-warfarin clearance and lower maintenance dosage. Decreased expression of VKORC1 resulting from the -1639G>A substitution has also been implicated in lower warfarin dose requirements. We investigated the additional contribution of th...

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Source

Identifiers

PMID: 17510308
DOI: 10.1373/clinchem.2006.078139

Genes

VKORC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17510308-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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Estimation of warfarin maintenance dose based on VKORC1 (-1639 G>A) and CYP2C9 genotypes.PMID 17510308Read ↗

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