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Article

Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.

International journal of epidemiology - 1 Feb 2007

Lubin Jay H, Kogevinas Manolis, Silverman Debra, Malats Núria, Garcia-Closas Montserrat, Tardón Adonina, Hein David W, Garcia-Closas Reina, Serra Consol, Dosemeci Mustafa, Carrato Alfredo, Rothman Nathaniel

Abstract excerpt

BACKGROUND: The N-acetyltransferase 2 (NAT2) enzyme detoxifies aromatic amines, an important class of carcinogens in tobacco smoke. Slow acetylation phenotype individuals have reduced detoxification capacity compared with those with a rapid/intermediate phenotype. Analysis of the Spanish Bladder Cancer Study found an odds ratio (OR) for slow acetylators relative to rapid/intermediate acetylators of 0.9 in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17510079
DOI: 10.1093/ije/dym043

Genes

NAT2

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Related research

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Evidence for an intensity-dependent interaction of NAT2 acetylation genotype and cigarette smoking in the Spanish Bladder Cancer Study.PMID 17510079Read ↗

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Joint effects of the N-acetyltransferase 1 and 2 (NAT1 and NAT2) genes and smoking on bladder carcinogenesis: a literature-based systematic HuGE review and evidence synthesis.Semantic proximity Read ↗

Meta-analysis of the relationship between slow acetylation of N-acetyl transferase 2 and the risk of bladder cancer.Semantic proximity Read ↗

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NAT2 slow acetylation and bladder cancer risk: a meta-analysis of 22 case-control studies conducted in the general population.Semantic proximity Read ↗

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NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses.Semantic proximity Read ↗

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