Article
The CYP1A2 genotype modifies the association between coffee consumption and breast cancer risk among BRCA1 mutation carriers.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 May 2007
Kotsopoulos Joanne, Ghadirian Parviz, El-Sohemy Ahmed, Lynch Henry T, Snyder Carrie, Daly Mary, Domchek Susan, Randall Susan, Karlan Beth, Zhang Phil, Zhang Shiyu, Sun Ping, Narod Steven A
Abstract excerpt
We have recently reported that, among BRCA1 mutation carriers, the consumption of caffeinated coffee was associated with a significant reduction in breast cancer risk. Because the metabolism of caffeine is primarily by CYP1A2, we examined whether or not the CYP1A2 genotype modifies the association between a history of coffee consumption and the risk of breast cancer. A common A to C polymorphism in the CYP1A2...
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