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BRCA1 May Modulate Neuronal Cell Cycle Re-Entry in Alzheimer Disease

1 Jan 2007

Abstract excerpt

In Alzheimer disease, neuronal degeneration and the presence of neurofibrillary tangles correlate with the severity of cognitive decline. Neurofibrillary tangles contain the antigenic profile of many cell cycle markers, reflecting a re-entry into the cell cycle by affected neurons. However, while such a cell cycle re-entry phenotype is an early and consistent feature of Alzheimer disease, the mechanisms...

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PMID: 17505559
DOI: 10.7150/ijms.4.140

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