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Increased p27, an essential component of cell cycle control, in Alzheimer's disease

26 Mar 2003

Abstract excerpt

A number of recent findings have demonstrated re-expression of cell cycle-related proteins in vulnerable neurones in Alzheimer's disease. We hypothesize that this attempt by neurones to re-enter mitosis is a response to external growth stimuli that leads to an abortive re-entry into the cell cycle and, ultimately, neuronal degeneration. In this study, to further delineate the role of mitotic processes in the...

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PMID: 12882323
DOI: 10.1046/j.1474-9728.2003.00042.x

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