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Article

Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 22 Oct 2008

Varvel Nicholas H, Bhaskar Kiran, Patil Anita R, Pimplikar Sanjay W, Herrup Karl, Lamb Bruce T

Abstract excerpt

Neurons subject to degeneration in Alzheimer's disease (AD) exhibit evidence of re-entry into a mitotic cell cycle even before the development of substantial AD brain pathology. In efforts to identify the initiating factors underlying these cell cycle events (CCEs), we have characterized the appearance of the neuronal CCEs in the genomic-based R1.40 transgenic mouse model of AD. Notably, R1.40 mice exhibit...

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Identifiers

PMID: 18945886
DOI: 10.1523/JNEUROSCI.2441-08.2008
PMCID: PMC2680286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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