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Article

A common haplotype in the G-protein-coupled receptor gene GPR74 is associated with leanness and increased lipolysis.

American journal of human genetics - 1 Jun 2007

Dahlman Ingrid, Dicker Andrea, Jiao Hong, Kere Juha, Blomqvist Lennart, van Harmelen Vanessa, Hoffstedt Johan, Borch-Johnsen Knut, Jorgensen Torben, Hansen Torben, Pedersen Oluf, Laakso Markku, Arner Peter

Abstract excerpt

The G-protein-coupled receptor GPR74 is a novel candidate gene for body weight regulation. In humans, it is predominantly expressed in brain, heart, and adipose tissue. We report a haplotype in the GPR74 gene, ATAG, with allele frequency ~4% in Scandinavian cohorts, which was associated with protection against obesity in two samples selected for obese and lean phenotypes (odds ratio for obesity 0.48 and 0.62;...

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Identifiers

PMID: 17503329
DOI: 10.1086/518445
PMCID: PMC1867099

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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