Article
hzAnalyzer: detection, quantification, and visualization of contiguous homozygosity in high-density genotyping datasets.
Genome biology - 1 Jan 2011
Johnson Todd A, Niimura Yoshihito, Tanaka Hiroshi, Nakamura Yusuke, Tsunoda Tatsuhiko
Abstract excerpt
The analysis of contiguous homozygosity (runs of homozygous loci) in human genotyping datasets is critical in the search for causal disease variants in monogenic disorders, studies of population history and the identification of targets of natural selection. Here, we report methods for extracting homozygous segments from high-density genotyping datasets, quantifying their local genomic structure, identifying...
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