Cell Cycle Regulation Targets of MYCN Identified by Gene Expression Microarrays

Abstract excerpt

BACKGROUND: We have previously shown that MYCN knockdown causes a G1 arrest in MYCN amplified (MNA), p53 wild type (wt) and p53 mutant MNA neuroblastoma cell lines, with increases in p21(WAF1) and hypo RB in p53 wt cell lines. HYPOTHESIS: MYCN acts by inhibiting p21(WAF1), and also by p21(WAF1) independent mechanisms to override the G1 checkpoint in exponentially growing cells. METHODS: Genes potentially...

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