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Article

CDK4 inhibition restores G₁-S arrest in<i><i>MYCN</i>-</i>amplified neuroblastoma cells in the context of doxorubicin-induced DNA damage

28 Mar 2013

Abstract excerpt

Relapse with drug-resistant disease is the main cause of death in MYCN-amplified neuroblastoma patients. MYCN-amplified neuroblastoma cells in vitro are characterized by a failure to arrest at the G(1)-S checkpoint after irradiation- or drug-induced DNA damage. We show that several MYCN-amplified cell lines harbor additional chromosomal aberrations targeting p53 and/or pRB pathway components, including...

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PMID: 23462184
DOI: 10.4161/cc.24091

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