Article
BCRP gene polymorphisms are associated with susceptibility and survival of diffuse large B-cell lymphoma.
Carcinogenesis - 1 Aug 2007
Hu Li-Li, Wang Xiao-Xiao, Chen Xiaochao, Chang Jianhua, Li Caixia, Zhang Yan, Yang Jine, Jiang Wenqi, Zhuang Shi-Mei
Abstract excerpt
To date, the biological significance of breast cancer resistance protein (BCRP) G34A and C421A polymorphisms is largely unknown. Analysis of these two polymorphisms in 156 diffuse large B-cell lymphoma (DLBCL) patients and 376 control subjects revealed an increased risk of DLBCL associated with variant BCRP 421 genotypes (CA and AA), when compared with the wild-type CC genotype [odds ratio = 1.49, 95% confidence...
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