Article
Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.
Blood - 1 Oct 2008
Habermann Thomas M, Wang Sophia S, Maurer Matthew J, Morton Lindsay M, Lynch Charles F, Ansell Stephen M, Hartge Patricia, Severson Richard K, Rothman Nathaniel, Davis Scott, Geyer Susan M, Cozen Wendy, Chanock Stephen J, Cerhan James R
Abstract excerpt
To evaluate the hypothesis that host germ line variation in immune genes is associated with overall survival in diffuse large B-cell lymphoma (DLBCL), we genotyped 73 single nucleotide polymorphisms (SNPs) from 44 candidate genes in 365 DLBCL patients diagnosed from 1998 to 2000. We estimated hazard ratios (HRs) and 95% confidence intervals (CIs) for the association of SNPs with survival after adjusting for...
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