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Article

Antirepression as a second mechanism of transcriptional activation by a minor groove binding protein.

Molecular microbiology - 1 Apr 2007

Smits Wiep Klaas, Hoa Tran Thu, Hamoen Leendert W, Kuipers Oscar P, Dubnau David

Abstract excerpt

Competence for genetic transformation in the bacterium Bacillus subtilis is a bistable differentiation process governed by the minor groove DNA binding protein ComK. No detectable comK transcription occurs in the absence of an intact comK gene, indicating that ComK has auto-activating properties. ComK auto-stimulation, which is dependent on ComK binding to the comK promoter, is a critical step in competence...

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Share to Bacterial Proteins
Share to Binding Sites
Share to DNA, Bacterial

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA-Directed RNA Polymerases

Share to Nucleic Acid Conformation

Share to Promoter Regions, Genetic

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Source

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Identifiers

PMID: 17493123
DOI: 10.1111/j.1365-2958.2007.05662.x
PMCID: PMC3831528

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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