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Article

Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor.

The EMBO journal - 16 Nov 1998

Turgay K, Hahn J, Burghoorn J, Dubnau D

Abstract excerpt

Competence is a physiological state, distinct from sporulation and vegetative growth, that enables cells to bind and internalize transforming DNA. The transcriptional regulator ComK drives the development of competence in Bacillus subtilis. ComK is directly required for its own transcription as well as for the transcription of the genes that encode DNA transport proteins. When ComK is sequestered by binding to a...

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Identifiers

PMID: 9890793
DOI: 10.1093/emboj/17.22.6730
PMCID: PMC1171018

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor.PMID 9890793Read ↗

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MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature.Semantic proximity Read ↗

Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.Semantic proximity Read ↗

Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence development in Bacillus subtilis.Semantic proximity Read ↗

Adaptor Protein MecA Is a Negative Regulator of the Expression of Late Competence Genes in Streptococcus thermophilusSemantic proximity Read ↗

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The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis.Semantic proximity Read ↗

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