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Article

Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development.

Molecular microbiology - 1 May 2005

Smits Wiep Klaas, Eschevins Caroline C, Susanna Kim A, Bron Sierd, Kuipers Oscar P, Hamoen Leendert W

Abstract excerpt

In Bacillus subtilis competence for genetic transformation develops only in a subpopulation of cells in an isogenic culture. The molecular mechanisms underlying this phenotypic heterogeneity are unknown. In this study, we stepwise simplify the signal transduction cascade leading to competence, yielding a strain devoid of all regulatory inputs for this process that have been identified so far. We demonstrate that...

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PMID: 15819618
DOI: 10.1111/j.1365-2958.2005.04488.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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