Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop.

doi:10.1111/j.1365-2958.2005.04592.x

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Article

Bistability in the Bacillus subtilis K-state (competence) system requires a positive feedback loop.

Molecular microbiology - 1 May 2005

Maamar Hédia, Dubnau David

Abstract excerpt

High expression of the transcriptional activator ComK occurs in 10-20% of the cells in stationary phase cultures of Bacillus subtilis strain 168. ComK drives the expression of more than 100 genes constituting the semidormant K-state, distinct from sporulation and vegetative growth. Among the genes so activated are those that permit competence for genetic transformation. We have addressed the origin of bistability...

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Identifiers

PMID: 15819619
DOI: 10.1111/j.1365-2958.2005.04592.x
PMCID: PMC3831615

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.