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Article

Regulation of competence-specific gene expression by Mec-mediated protein-protein interaction in Bacillus subtilis.

Proceedings of the National Academy of Sciences of the United States of America - 21 Jun 1994

Kong L, Dubnau D

Abstract excerpt

The expression of competence genes in Bacillus subtilis is controlled by a signal transduction cascade which increases the expression of a competence transcription factor (CTF, encoded by comK) during the transition from exponential growth to stationary phase. The transcription of CTF (ComK) is decreased by the product of the mecA gene, and this inhibition is relieved in response to an unknown signal received...

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Identifiers

PMID: 8016067
DOI: 10.1073/pnas.91.13.5793
PMCID: PMC44083

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Regulation of competence-specific gene expression by Mec-mediated protein-protein interaction in Bacillus subtilis.PMID 8016067Read ↗

The regulation of competence transcription factor synthesis constitutes a critical control point in the regulation of competence in Bacillus subtilis.Semantic proximity Read ↗

Competence in Bacillus subtilis is controlled by regulated proteolysis of a transcription factor.Semantic proximity Read ↗

comK acts as an autoregulatory control switch in the signal transduction route to competence in Bacillus subtilis.Semantic proximity Read ↗

Mutational analysis of ComS: evidence for the interaction of ComS and MecA in the regulation of competence development in Bacillus subtilis.Semantic proximity Read ↗

Distinct roles of ComK1 and ComK2 in gene regulation in Bacillus cereus.Semantic proximity Read ↗

Transcriptional regulation of comC: evidence for a competence-specific transcription factor in Bacillus subtilis.Semantic proximity Read ↗

MecB of Bacillus subtilis, a member of the ClpC ATPase family, is a pleiotropic regulator controlling competence gene expression and growth at high temperature.Semantic proximity Read ↗

Adaptor Protein MecA Is a Negative Regulator of the Expression of Late Competence Genes in Streptococcus thermophilusSemantic proximity Read ↗

Stripping Bacillus: ComK auto-stimulation is responsible for the bistable response in competence development.Semantic proximity Read ↗

Suppression of early competence mutations in Bacillus subtilis by mec mutations.Semantic proximity Read ↗

Involvement of ClpX protein in the post-transcriptional regulation of a competence specific transcription factor, ComK protein, of Bacillus subtilis.Semantic proximity Read ↗

Loss-of-function mutations in yjbD result in ClpX- and ClpP-independent competence development of Bacillus subtilis.Semantic proximity Read ↗

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