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Article

High frequency of vitamin B12 deficiency in asymptomatic individuals homozygous to MTHFR C677T mutation is associated with endothelial dysfunction and homocysteinemia.

American journal of physiology. Heart and circulatory physiology - 1 Jul 2007

Zittan E, Preis M, Asmir I, Cassel A, Lindenfeld N, Alroy S, Halon D A, Lewis B S, Shiran A, Schliamser J E, Flugelman M Y

Abstract excerpt

The aim of this study was to examine the association of homozygosity for the methylenetetrahydrofolate reductase (MTHFR) C677T mutation and vitamin B12 deficiency in 360 asymptomatic individuals and to investigate forearm endothelial function in C677T homozygotes. MTHFR C677T mutation and levels of vitamin B12, folic acid, and homocysteine were measured in study participants. Frequency of homozygosity for the...

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Source

Identifiers

PMID: 17449548
DOI: 10.1152/ajpheart.01189.2006

Genes

MTHFR

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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