RNAi Screen Reveals an Abl Kinase-Dependent Host Cell Pathway Involved in Pseudomonas aeruginosa Internalization

Abstract excerpt

Internalization of the pathogenic bacterium Pseudomonas aeruginosa by non-phagocytic cells is promoted by rearrangements of the actin cytoskeleton, but the host pathways usurped by this bacterium are not clearly understood. We used RNAi-mediated gene inactivation of approximately 80 genes known to regulate the actin cytoskeleton in Drosophila S2 cells to identify host molecules essential for entry of P....

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Aquaculture disease management and microbiota
• Share to Invertebrate Immune Response Mechanisms
• Share to Research on Leishmaniasis Studies