Article
Molecular mutation profile of Pfcrt and Pfmdr1 in Plasmodium falciparum isolates from Bioko Island, Equatorial Guinea.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Dec 2015
Li Jian, Chen Jiangtao, Xie Dongde, Eyi Urbano Monsuy, Matesa Rocio Apicante, Obono Maximo Miko Ondo, Ehapo Carlos Sala, Yang Liye, Yang Huitian, Lin Min, Wu Wanjun, Wu Kai, Li Shan, Chen Zongyun
Abstract excerpt
BACKGROUND: Antimalarial drug resistance is a primary public health problem. Haplotypes of pfcrt and pfmdr1 gene have been implicated to be molecular markers of chloroquine (CQ) resistance. This study aims to explore mutation distribution of Pfcrt and Pfmdr1 in Bioko Island, Equatorial Guinea (EG). METHODS: Blood samples were collected from different districts of Bioko. The single nucleotide polymorphisms in...
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