Article
CYP19 TCT tri-nucleotide Del/Del genotype is a susceptibility marker for prostate cancer in a Taiwanese population.
Urology - 1 May 2007
Huang Yu-Chuen, Chen Marcelo, Lin Ming-Wei, Chung Ming-Yi, Chang Yen-Hwa, Huang William Ji-Shian, Wu Tony T, Hsu Jong-Ming, Yang Stone, Chen Yi-Ming Arthur
Abstract excerpt
OBJECTIVES: The CYP19 gene encodes aromatase--a key enzyme involved in the conversion of androstenedione/testosterone to estrone/estradiol. In this study, we analyzed the association between the TCT insertion (Ins)/deletion (Del) and TTTA repeat polymorphisms of CYP19 and prostate cancer (PCa). METHODS: Automated sequencer with GeneScan software was used to determine the CYP19 gene polymorphisms in peripheral...
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